曲伏前列素
Travoprost
Propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
別名: Travatan · Travoprostum
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Primary glaucoma / Lens subluxation / Posterior luxation | 1 drop per eye | topical | once daily (evening), or q8-12h | — | 🌍 EU |
- Primary glaucoma / Lens subluxation / Posterior luxation: Often used in conjunction with other topical antiglaucoma drugs such as carbonic anhydrase inhibitors.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
概覽
曲伏前列素是一種局部眼科前列腺素F2α類似物，主要用於獸醫學中治療原發性犬青光眼。它能快速有效降低眼內壓（IOP），常被用於急性原發性青光眼的緊急處理。其活性與拉坦前列素（latanoprost）相當，經常與其他局部抗青光眼藥物（如碳酸酐酶抑制劑）合併使用。
臨床警告： 禁忌用於葡萄膜炎和晶狀體前脫位，但可能對晶狀體半脫位和後脫位有幫助。避免用於懷孕動物。
作用機轉
Acts as an agonist for prostaglandin F receptors → increases uveoscleral outflow of aqueous humor → significantly reduces intraocular pressure (IOP).
安全性與警告
禁忌症
- Uveitis
- Anterior lens luxation
- Pregnancy
不良反應
- Miosis (profound in dogs)
- Conjunctival hyperaemia
- Mild ocular irritation
- Increased iridal pigmentation (noted in humans, but not typically in dogs)
注意事項
Normal safety and handling precautions should be observed.
Warning: Avoid use in pregnant animals. Prostaglandin analogues can be absorbed systemically and may carry risks for pregnant handlers.
藥物交互作用
Incompatible; do not use in conjunction
監測
- Intraocular pressure (IOP)
- Signs of ocular irritation or inflammation
- Pupil size (miosis)
藥物動力學
吸收
Absorbed through the cornea where it is hydrolyzed to the active free acid.
分佈
Primarily acts locally within the eye.
代謝
Hydrolyzed by esterases in the cornea to its biologically active free acid.
排除
Systemically absorbed drug is rapidly metabolized and excreted primarily via urine.
過量
No specific veterinary information provided. Overdosage is likely to cause profound miosis, conjunctival hyperaemia, and ocular irritation. Flush the eye with sterile saline if significant accidental overexposure occurs.
可用產品
劑型
- Ophthalmic solution: 40 μg/ml (0.004%) in 2.5 ml bottle
人用標示
- Travatan 40 μg/ml (0.004%) ophthalmic solution
各地核准狀態
Human authorized product used off-label under the cascade (POM).
Human authorized product used off-label under the cascade (POM).
暫無法規資料: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Store according to manufacturer guidelines, typically at room temperature (below 25°C). Discard 4 weeks after first opening.
飼主須知
- 嚴格按照處方滴入眼藥水。
- 如果使用多種眼藥水，請在兩次用藥之間至少等待5-10分鐘，以免沖洗掉前一種藥物。
- 使用後請徹底洗手。
警告： 孕婦應極度謹慎處理或完全避免接觸此藥物，因為前列腺素可能會影響懷孕。請勿用於懷孕的寵物。
- 可能會導致眼睛發紅或瞳孔縮小（縮瞳）；如果寵物眼睛看起來疼痛或受刺激，請聯繫您的獸醫。
VetSheet 藥物參考供合格獸醫專業人員作臨床決策輔助之用，不能取代專業判斷或廠商最新仿單。