維生素E / 硒
Vitamin E / Selenium
Alpha-tocopherol / Sodium selenite
別名: Emulsivit E-300 · Vital E-300 · Equ-SeE · Equ-Se5E · Mu-Se · Bo-Se · L-Se · E-Se · Seletoc · Aquasol E · Nutr-E-Sol · Alpha-tocopherol · Sodium selenite
由 VetSheet 獸醫團隊審訂更新於 2026年4月5日本內容以實證獸醫文獻為本
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
各物種劑量
🌎 NA — North America🌍 EU — Europe
狗
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Adjunctive treatment of discoid lupus erythematosus, canine demodicosis or acanthosis nigricans | 200-400 Units PO three times daily | PO | q8h | — | 🌎 NA |
| Adjunctive treatment of cholestatic hepatopathies; necroinflammatory hepatopathies | 10-15 Units/kg per day PO as alpha-tocopherol acetate | PO | q24h | — | 🌎 NA |
| Adjunctive treatment of copper-associated hepatopathy | 400-600 Units PO per day | PO | q24h | — | 🌎 NA |
| Treatment of tocopherol deficiency associated with exocrine pancreatic disease | 100-400 Units PO once daily for one month then every 1-2 weeks as needed | PO | q24h | 1 month, then q1-2 weeks | 🌎 NA |
| Vitamin E/Selenium deficiency (using Seletoc) | Initially, 1 mL per 20 pounds of body weight (minimum 0.25 mL; maximum 5 mL) SC, or IM in divided doses in 2 or more sites. Repeat dose at 3 day intervals until satisfactory results then switch to maintenance dose. Maintenance dose: 1 mL per 40 lbs body weight (minimum 0.25 mL) repeat at 3-7 day intervals (or longer) to maintain. | SC/IM | q3d initially, then q3-7d | — | 🌎 NA |
- Adjunctive treatment of discoid lupus erythematosus, canine demodicosis or acanthosis nigricans: Variable efficacy, but relatively innocuous at these dosages
- Vitamin E/Selenium deficiency (using Seletoc): If no response in 14 days reevaluate.
貓
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Treatment of tocopherol deficiency associated with exocrine pancreatic disease | 30 Units PO once daily for one month then every 1-2 weeks as needed | PO | q24h | 1 month, then q1-2 weeks | 🌎 NA |
| Adjunctive treatment of hepatic lipidosis | 10 Units/kg once PO once daily | PO | q24h | — | 🌎 NA |
馬
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Adjunctive treatment of ionophore (monensin) toxicity | 4-12 Units/kg PO once daily | PO | q24h | — | 🌎 NA |
| Adjunctive therapy for EPM | 8000-9000 Units PO per day | PO | q24h | — | 🌎 NA |
| Adjunctive therapy for metabolic syndrome | 10,000 Units PO once daily | PO | q24h | — | 🌎 NA |
| Adjunctive treatment of perinatal asphyxia syndrome (hypoxic ischemic encephalopathy) | Foals: 4,000 Units PO once daily; Mares: 10,000 Units PO once daily | PO | q24h | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using E-Se) | 1 mL/100 lbs. body weight slow IV or deep IM (in 2 or more sites; gluteal or cervical muscles). May be repeated at 5-10 day intervals. | IV/IM | q5-10d | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using E-Se): Give slowly when administering IV.
牛
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Vitamin E/Selenium deficiency (using Mu-Se) | For weanling calves: 1 mL per 200 lbs. body weight IM or SC. For breeding beef cows: 1 mL per 200 lbs. body weight during middle third of pregnancy and 30 days before calving IM or SC. | IM/SC | Variable | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using Bo-Se) | Calves: 2.5-3.75 mL/100 lbs body weight (depending on severity of condition and geographical area) IM or SC. | IM/SC | Single dose | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using Mu-Se): Slaughter withdrawal = 30 days.
- Vitamin E/Selenium deficiency (using Bo-Se): Slaughter withdrawal = 30 days.
豬
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Vitamin E/Selenium deficiency (using Bo-Se) | Sows and weanling pigs: 1mL/40 lbs. body weight IM or SC (1 mL minimum). | IM/SC | Single dose | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using L-Se) | Baby Pigs: 1 mL SC or IM. | SC/IM | Single dose | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using Bo-Se): Do not use on newborn pigs. Slaughter withdrawal = 14 days.
- Vitamin E/Selenium deficiency (using L-Se): Slaughter withdrawal = 14 days.
羊
| 適應症 | 劑量 | 途徑 | 頻次 | 療程 | 地區 |
|---|---|---|---|---|---|
| Vitamin E/Selenium deficiency (using Bo-Se) | Lambs (2 weeks of age or older): 1 mL per 40 lbs. body weight IM or SC (1 mL minimum). Ewes: 2.5 mL/100 lbs. body weight IM or SC. | IM/SC | Single dose | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using L-Se) | Lambs: 1 mL SC or IM in newborns and 4 mL SC or IM in lambs 2 weeks of age or older | SC/IM | Single dose | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using Bo-Se): Slaughter withdrawal = 14 days.
- Vitamin E/Selenium deficiency (using L-Se): Slaughter withdrawal = 14 days.
劑量為合格獸醫專業人員的臨床參考。請務必對照最新仿單及個別病患確認。
概覽
維生素E和硒經常一起使用，因為它們具有協同的抗氧化特性，儘管維生素E也廣泛作為獨立的補充劑使用。
- 維生素E（α-生育酚） 是一種脂溶性維生素，對於保護細胞膜免受氧化損傷至關重要。它被輔助用於各種皮膚病（盤狀紅斑狼瘡、毛囊蟲症）、肝臟和神經系統疾病。
- 硒 是一種微量礦物質，作為抗氧化酶的關鍵輔因子。複方產品主要用於治療或預防硒-生育酚缺乏症 (STD)，例如家畜的白肌病。
臨床提示： 雖然維生素E的安全範圍很廣，但過量攝入硒具有高度毒性。複方產品必須根據硒的濃度仔細計算劑量，並且只能用於FDA批准的物種。
作用機轉
Both Vitamin E and Selenium are intricately involved in the cellular metabolism of sulfur and the prevention of oxidative stress.
- Vitamin E acts as a potent biological free radical scavenger. It prevents the oxidation of polyunsaturated fatty acids within cellular and subcellular membranes.
- Selenium is an essential structural component of the enzyme glutathione peroxidase → this enzyme catalyzes the reduction of lipid hydroperoxides to their corresponding alcohols, neutralizing their potential to cause cellular damage.
Together, they protect against red blood cell hemolysis and prevent the destructive action of peroxidase on unsaturated bonds in cell membranes.
安全性與警告
禁忌症
- Use of combination products in non-FDA approved species
- Use of Bo-Se in newborn pigs
不良反應
- Anaphylactoid reactions
- Transient muscle soreness at injection sites (IM)
- Selenium toxicity (depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness, garlic breath)
注意事項
Vitamin E/selenium products should only be used in the species for which they are FDA-approved. Because selenium can be extremely toxic, the promiscuous use of these products cannot be condoned. Give slowly when administering intravenously to horses.
藥物交互作用
Large doses of vitamin E may delay the hematologic response to iron therapy in patients with iron deficiency anemia.
May reduce the absorption of orally administered vitamin E.
Absorption, utilization, and storage may be enhanced by vitamin E.
Vitamin E may increase the effects of warfarin.
監測
- Clinical efficacy
- Blood selenium levels (when using combination products)
- Glutathione peroxidase activity (optional)
藥物動力學
吸收
After absorption, vitamin E is transported in the circulatory system via beta-lipoproteins. Absorption of vitamin E may be impaired in patients with severe cholestatic liver disease or in animals with fat malabsorption syndromes.
分佈
Vitamin E is distributed to all tissues and stored in adipose tissue. It is only marginally transported across the placenta.
代謝
Vitamin E is metabolized in the liver.
排除
Vitamin E is excreted primarily into the bile.
過量
Selenium is quite toxic in overdose quantities, but has a fairly wide safety margin. Cattle have tolerated chronic doses of 0.6 mg/kg/day with no adverse effects (approximate therapeutic dose is 0.06 mg/kg).
Clinical signs of selenium toxicity include:
- Depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness
- A distinct 'garlic' odor on the breath
- Horses: May become blind, paralyzed, slough their hooves, and lose hair from the tail and mane.
- Dogs: May exhibit anorexia, vomiting, and diarrhea at high dosages.
Large overdoses of vitamin E alone can cause coagulopathies.
可用產品
劑型
- Injection
- Oral powder
- Oral liquid
- Tablets
- Capsules
獸醫用
- Vitamin E Injection: 300 mg/mL (Emulsivit E-300, Vital E-300)
- Vitamin E/Selenium Oral: Equ-SeE, Equ-Se5E
- Vitamin E/Selenium Injection: Mu-Se (5 mg Se/mL), Bo-Se (1 mg Se/mL), L-Se (0.25 mg Se/mL), E-Se (2.5 mg Se/mL), Seletoc (1 mg Se/mL)
人用標示
- Vitamin E Tablets: 100 Units, 200 Units, 400 Units, 500 Units & 800 Units
- Vitamin E Capsules: 100 Units, 200 Units, 400 Units & 1000 Units
- Vitamin E Drops: 15 Units/0.3 mL
- Vitamin E Liquid: 15 Units/30 mL, 798 Units/30 mL
各地核准狀態
暫無法規資料: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
儲存與穩定性
Vitamin E/Selenium for injection should be stored at temperatures less than 25°C (77°F).
飼主須知
- 嚴格遵守劑量： 絕對不要超過處方劑量。雖然維生素E相對安全，但過量補充硒具有高度毒性。
- 中毒跡象： 如果您發現寵物呼吸有「大蒜」味、極度虛弱、步態不穩、嘔吐或呼吸困難，請立即聯繫您的獸醫。
- 給藥方式： 如果給予口服液或膠囊，請遵循獸醫關於餵食的指示（通常與食物一起給予，以促進脂溶性維生素的吸收）。
- 儲存： 將所有補充劑放在兒童和動物接觸不到的地方，以防誤食。
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